Diagnosis of diseases non-invasively make the patient comfortable, therefore this technique becoming more popular. Among the non-invasive method is diagnosis by nuclear technique using radiopharmaceuticals. The preparation of the radiopharmaceuticals can be done by adding certain radionuclide solution to the dry kit following the instruction of kit preparation that usually enclosed in the kit packaging. The quality of obtained radiopharmaceuticals depend on the quality of the kit and hence the quality of the organ imaging and diagnosis accuracy depend on the quality of radiopharmaceuticals. In some cases, the radiopharmaceutical kit damage in short period of time during storage, resulting poor labeling efficiency and inaccurate diagnosis. This article deals with the chemical and physical evaluation of the kit , as well as the description about how to improve the kit,s quality. Parameters need to evaluate are: pH, radiochemical purity, lipophylicity, protein–plasma binding and electrical charge. Anomaly in physical and chemical properties of the kit caused by some cases during proses such as: raw materials, composition of kit, vacuum system of the kit, and the performance of the apparatus used are also discussed.
Key words: radiopharmaceuticals kit, 99mTc, organ imaging
Misyetti
Pusat Teknologi Nuklir Bahan dan Radiometri
Key words: radiopharmaceuticals kit, 99mTc, organ imaging
Misyetti
Pusat Teknologi Nuklir Bahan dan Radiometri
