Computer-aided systems analysis of tumor treatment.


In this contribution the attempt is made to apply methods of systems analysis, control theory and computer science to the process of abnormal (malignant) cell growth. The modelling approach starts on the basis of experimentally gained data of normal cells and tumor cells. Complicated algorithms are developed step by step describing the division of an individual cell as well as the interactions among the single cells. The time behaviour and the spatial (three-dimensional) tumor growth are simulated with a large digital computer. The main goal of the simulation under consideration is to study different methods of tumor treatment (surgery, radiotherapy, chemotherapy) and to determine an optimum method and time of therapy prior to clinical treatment. The proceeding is discussed in detail by illustrative examples. (orig.). Duechting,-W.; Vogelsaenger,-T. (Gesamthochschule Siegen, Gummersbach (Germany, F.R.). Lab. fuer Steuer- und Regelungstechnik)