Structure of Biologically Active Organotin(IV) Dithiocarbamates


The diorganotin(IV) complexes of dithiocarbamates derived from trom N-ethyl-n-propylamine (EtPrdtc), 2-dimethylaminoethylamine (Me2Etdtc), 3-dimethlyamino-l-propylamine (Me2Prdtc), p-tolylmethanamine (TyIMetdtc) and N-methyl-I-phenylmethanamine (MePhMetdtc) have been synthesized and characterized. Single crystal X-ray diffraction studies on Ph3Sn(EtPrdtc), Me2Sn(MePhMetdtc:h and BU2Sn(MePhMetdtc:hshowed that the complexes adopted a monoclinic system with space group P(2)/n, P21/n and C2/c, respectively. The Ph3Sn(EtPrdtc) complex adopted a trigonal pyramidal structure while the Me2Sn(MePhMetdtc)2 and BU2Sn(MePhMetdtc:hcomplexes displayed structures which may be described as distorted octahedrons. Cytotoxicity test using HL60 cells (human promyelocytic leukemic) showed that only Me2Sn(M~Etdtc), Me2Sn(MePhMetdtc:h and BU2Sn(MePhMetdtc)2complexes were active. The rest of the complexes did not show cytotoxicity behaviour towards HL60 cells. Keywords: Organotin dithiocarbamates, Biologically active, Structure.Y. Farina, M. Sanuddin and B. M. Yamin School of Chemical Sciences and Food Technology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia. 43600 UKM Bangi, Selangor, Malaysia