Cisadane River is one of the big rivers that crossing West Java and Banten Province. Cisadane Water Rivers has been used for drinking water resource. However, the pollutant loading in this river increase every day. Therefore, the investigation regarding to the water quality monitoring is important to carry out. The investigation was carried out in period of year 2003 - 2005. The investigation was carried out based on (1) The Class I of water quality criteria under the government regulation number 82/2001 and (2) calculation of Averages Score Per Taxon benthos. The grab method was applied in sampling for 14 locations stretched along the river at June and August. Those locations started from upper reaches to the down stream are Muara Jaya, Pancasan, karya Bhakti, Jasmin, Karihkil, Kranggan, Cilenggang, Ciheuni, Gading Serpong, Robinson, Pasar Baru, Bayur, Kelor and Kali Baru. Where, drinking water installation was built in Kranggan and Pasar Baru. The result of the investigation showed that Dissolve Oxygen was significantly decreased until less than 6 mg/L (Water Quality Criteria) from Gading Serpong to Kelor and reached until 3 mg/L at Kali Baru. DHL (The conductivity) was increased until more than 500 S/cm at Kelor and Kali Baru. The Biological Oxygen Demand (BOD) was fluctuated from more than 2 mg/L (Water Quality Criteria) until 10 mg/L (at Pasar Baru and KaIi Baru). The Chemical Oxygen Demand (COD) was also fluctuated at all locations from more than 10 mg/L (Water Quality Criteria) until 50 mg/L (at Pasar Baru). The NH3 was increased up to 25 mg/L in 2005. The highest value of P04 was found at Bayur as 0.2 mg/L and between 0.1- 0.2 mg/L at Kelor and Kali Baru. The MBAS(Detergent) value in almost all locations were more than 0.2 mg/L (Water Quality Criteria) and was increased about 8 times than Water Quality Criteria in August 2005. Dissolved metal (Cu and Mn) was increased at the points from upper reaches to the down stream. The highest concentration of Cu was found as 10 ug/L at Bayur (Water Quality Criteria is 20 ug/L), Mn was found as 0.3 mg/L at Kali Baru (Water Quality Criteria is 0.1 mg/L). However, dissolved Pb metal was fluctuated up to 441 ug/L at Kelor in 2004 year. Number of total Coliform bacteria for all locations were found in range of 100,000 - close to 1,000,000 per sample. That was over than water quality criteria regulations as 1000 per 100 samples. Number of E. coli bacteria was decrease at the points from upper reaches to the down stream but was also over than criteria in regulations as 100 per 100 samples. Based on the average score Per taxon (ASPT)of bentos calculations, water quality criteria found at Muara Jaya was less interference, at Jasmin was middle interference and at kali Baru was heavy interference. From the result mentioned above, we concluded that Cisadane River (from upper reaches to the down stream) water quality was decreased during 2003-2005. Almost all values had over than the government regulation number 82/2001 (The Class I Water Quality Criteria) as like DO, COD, BOD, MBAS, total Coliform bacteria number, E. coli bacteria number and dissolved metal (Cu, Mn). Those parameters should have more attentions regarding to management of Cisadane River management in future. The tendency of water quality decline from upper reaches to down stream was contributed by calculation of average score per taxon of sensitive benthas as an L. •.dicator and both were mutually supported each other. Kay words: Chemical indicator, Biological indicator, Cisadane river quality. Sri Unon Purwati Pusat Sarana Pengendalian Dampak Lingkungan-Kementrian Negara Lingkungan Hidup